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KMID : 0605720160220030173
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Journal of the Korean Society of Biological Therapies in Psychiatry
2016 Volume.22 No. 3 p.173 ~ p.179
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Comparison of Neurocognitive Function between Subjects with Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Normal Controls
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Kim Seok-Man
Kang Suk-Hoon
Chung Hae-Gyung
Choi Jin-Hee
So Hyung-Seok
Kim Tae-Yong
Kim Tea
Yoon In-Young
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Abstract
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Objectives：Rapid eye movement(REM) sleep behavior disorder(RBD) is a parasomnia characterized by loss of normal atonia during REM sleep and dream enacting behavior(DEB) including vocalizations, striking behaviors or violent movements. A proportion of RBD patients had showed mild cognitive decline, but it is controversial. This study has an aim to compare neurocognitive functions between idiopathic RBD(iRBD) and normal subjects in the Korean elderly.
Methods：Twenty-six iRBD subjects and 25 normal controls were selected by polysomnography, brain magnetic resonance imaging and clinical interview with psychiatrist. All the subjects completed the Korean version of the consortium to establish a registry for Alzheimer’s disease neuropsychological battery(CERAD-KN) as an objective cognitive measure and subjective memory complaints questionnaire(SMCQ). Additionally Pittsburgh sleep quality index (PSQI) for sleep quality, the Epworth sleepiness scale(ESS) for daytime sleepiness and the Korean version of the geriatric depression scale(GDS) for depressive symptoms were done.
Results：iRBD subjects showed poorer sleep quality with PSQI than normal controls, but there were no differences in other sleep parameters between groups. In the neurocognitive function test, iRBD subjects showed higher SMCQ score and lower score of Digit span backward test than normal controls.
Conclusion：In the elderly, subjects with iRBD had subjective memory complaints and impaired attention function, but not other objective cognitive measures. As attention function as well as subjective memory complaints might an indicator for cognitive disorders, iRBD patients with mild cognitive decline needs to be adequately controlled.
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KEYWORD
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Idiopathic REM sleep behavior disorder, Neurocognitive function, Neurodegenerative disorder, Synucleinopathy, Sleep quality
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